Synthesis, Biological Evaluation and Low-Toxic Formulation Development of Glycosylated Paclitaxel Prodrugs

Synthesis, Biological Evaluation and Low-Toxic Formulation Development of Glycosylated Paclitaxel Prodrugs

Paclitaxel (PTX) is a famous anti-cancer drug with poor aqueous solubility. In clinical practices, Cremophor EL (polyethoxylated castor oil), a toxic surfactant, is used for dissolution of PTX, which accounts for serious side effects. In the present study, a single glucose-conjugated PTX prodrug (SG...

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Bibliographic Details
Main Authors: Yukang Mao, Yili Zhang, Zheng Luo, Ruoting Zhan, Hui Xu, Weiwen Chen, Huicai Huang
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:Molecules
Subjects:
paclitaxel
prodrug
solubility
anti-cancer
toxic surfactant
Online Access:https://www.mdpi.com/1420-3049/23/12/3211

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https://www.mdpi.com/1420-3049/23/12/3211

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