Human Dopaminergic Neurons Lacking PINK1 Exhibit Disrupted Dopamine Metabolism Related to Vitamin B6 Co-Factors

Human Dopaminergic Neurons Lacking PINK1 Exhibit Disrupted Dopamine Metabolism Related to Vitamin B6 Co-Factors

Summary: PINK1 loss-of-function mutations cause early onset Parkinson disease. PINK1-Parkin mediated mitophagy has been well studied, but the relevance of the endogenous process in the brain is debated.Here, the absence of PINK1 in human dopaminergic neurons inhibits ionophore-induced mitophagy and...

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Bibliographic Details
Main Authors: Christine Bus, Laimdota Zizmare, Marita Feldkaemper, Sven Geisler, Maria Zarani, Anna Schaedler, Franziska Klose, Jakob Admard, Craig J. Mageean, Giuseppe Arena, Petra Fallier-Becker, Aslihan Ugun-Klusek, Klaudia K. Maruszczak, Konstantina Kapolou, Benjamin Schmid, Doron Rapaport, Marius Ueffing, Nicolas Casadei, Rejko Krüger, Thomas Gasser, Daniela M. Vogt Weisenhorn, Philipp J. Kahle, Christoph Trautwein, Christian J. Gloeckner, Julia C. Fitzgerald
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:iScience
Subjects:
Molecular Biology
Molecular Neuroscience
Stem Cells Research
Omics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220309949

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http://www.sciencedirect.com/science/article/pii/S2589004220309949

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