Individual Human Cytotoxic T Lymphocytes Exhibit Intraclonal Heterogeneity during Sustained Killing

Individual Human Cytotoxic T Lymphocytes Exhibit Intraclonal Heterogeneity during Sustained Killing

The killing of antigen-bearing cells by clonal populations of cytotoxic T lymphocytes (CTLs) is thought to be a rapid phenomenon executed uniformly by individual CTLs. We combined bulk and single-CTL killing assays over a prolonged time period to provide the killing statistics of clonal human CTLs a...

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Bibliographic Details
Main Authors: Zilton Vasconcelos, Sabina Müller, Delphine Guipouy, Wong Yu, Claire Christophe, Sébastien Gadat, Salvatore Valitutti, Loïc Dupré
Format: Article
Language:English
Published: Elsevier 2015-06-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715005008

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http://www.sciencedirect.com/science/article/pii/S2211124715005008

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