The inflammatory molecules IL-1β and HMGB1 can rapidly enhance focal seizure generation in a brain slice model of temporal lobe epilepsy

The inflammatory molecules IL-1β and HMGB1 can rapidly enhance focal seizure generation in a brain slice model of temporal lobe epilepsy

Epilepsy is a neurological disorder characterized by a hyperexcitable brain tissue and unpredictable seizures, i.e., aberrant firing discharges in large neuronal populations. It is well established that proinflammatory cytokines, in addition to their canonical involvement in the immune response, hav...

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Bibliographic Details
Main Authors: Angela eChiavegato, Gabriele eLosi, Emanuele eZurolo, Eleonora eAronica, Giorgio eCarmignoto
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-06-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Astrocytes
Calcium
Seizures
Epileptogenesis
proinflammatory cytokines
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00155/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00155/full

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