Loss of JAK1 Drives Innate Immune Deficiency

Loss of JAK1 Drives Innate Immune Deficiency

The Janus kinase—signal transducers and activators of transcription (JAK-STAT) signaling pathway is critical in tuning immune responses and its dysregulation is tightly associated with cancer and immune disorders. Disruption of interleukin (IL)-15/STAT5 signaling pathway due to the loss of IL-15 rec...

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Bibliographic Details
Main Authors: Agnieszka Witalisz-Siepracka, Klara Klein, Daniela Prinz, Nicoletta Leidenfrost, Gernot Schabbauer, Alexander Dohnal, Veronika Sexl
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Immunology
Subjects:
JAK-STAT
natural killer cells
JAK1
JAK2
tumor surveillance
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.03108/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.03108/full

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