Carnosine Stimulates Macrophage-Mediated Clearance of Senescent Skin Cells Through Activation of the AKT2 Signaling Pathway by CD36 and RAGE

Carnosine Stimulates Macrophage-Mediated Clearance of Senescent Skin Cells Through Activation of the AKT2 Signaling Pathway by CD36 and RAGE

Background: Macrophages can selectively recognize and eliminate senescent cells, but this function is impaired with age, resulting in excessive accumulation of senescent cells in the skin, which ultimately causes skin aging. Therefore, enhancing the immune surveillance ability of macrophages to clea...

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Bibliographic Details
Main Authors: Xuenan Li, Kaiye Yang, Shuang Gao, Jungang Zhao, Guangrong Liu, Yu Chen, Haojie Lin, Wengang Zhao, Zhenlin Hu, Nuo Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Pharmacology
Subjects:
Akt2
senescent cell
macrophages
carnosine
skin aging
co-culture
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.593832/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2020.593832/full

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