Label-free SRM-based relative quantification of antibiotic resistance mechanisms in Pseudomonas aeruginosa clinical isolates

Label-free SRM-based relative quantification of antibiotic resistance mechanisms in Pseudomonas aeruginosa clinical isolates

Both acquired and intrinsic mechanisms play a crucial role in Pseudomonas aeruginosa antibiotic resistance. Many clinically relevant resistance mechanisms result from changes in gene expression, namely multidrug efflux pump overproduction, AmpC beta-lactamase induction or derepression, and inactivat...

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Bibliographic Details
Main Authors: Yannick eCharretier, Thilo eKöhler, Tiphaine eCecchini, Chloé eBardet, Abdessalam eCherkaoui, Catherine eLlanes, Pierre eBogaerts, Sonia eChatellier, Jean-Philippe eCharrier, Jacques eSchrenzel
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-02-01
Series:Frontiers in Microbiology
Subjects:
Pseudomonas aeruginosa
RT-qPCR
SRM
Carbapenem resistance
OprD porin
multidrug efflux system
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.00081/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.00081/full

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