TRIM41 is required to innate antiviral response by polyubiquitinating BCL10 and recruiting NEMO

TRIM41 is required to innate antiviral response by polyubiquitinating BCL10 and recruiting NEMO

Abstract Sensing of pathogenic nucleic acids by pattern recognition receptors (PRR) not only initiates anti-microbe defense but causes inflammatory and autoimmune diseases. E3 ubiquitin ligase(s) critical in innate response need to be further identified. Here we report that the tripartite motif-cont...

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Bibliographic Details
Main Authors: Zhou Yu, Xuelian Li, Mingjin Yang, Jiaying Huang, Qian Fang, Jianjun Jia, Zheng Li, Yan Gu, Taoyong Chen, Xuetao Cao
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-021-00477-8

Internet

https://doi.org/10.1038/s41392-021-00477-8

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