Towards a multiscale description of microvascular flow regulation: O2-dependent release of ATP from human erythrocytes and the distribution of ATP in capillary networks

Integration of the numerous mechanisms that have been suggested to contribute to optimization of O2 supply to meet O2 need in skeletal muscle requires a systems biology approach which permits quantification of these physiological processes over a wide range of length scales. Here we describe two ind...

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Bibliographic Details
Main Authors: Daniel eGoldman, Graham M. Fraser, Christopher G Ellis, Randy S. Sprague, Mary L. Ellsworth, Alan H. Stephenson
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-07-01
Series:Frontiers in Physiology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00246/full