Synaptic function is modulated by LRRK2 and glutamate release is increased in cortical neurons of G2019S LRRK2 knock-in mice

Synaptic function is modulated by LRRK2 and glutamate release is increased in cortical neurons of G2019S LRRK2 knock-in mice

Mutations in Leucine-Rich Repeat Kinase-2 (LRRK2) result in familial Parkinson’s disease and the G2019S mutation alone accounts for up to 30% in some ethnicities. Despite this, the function of LRRK2 is largely undetermined although evidence suggests roles in phosphorylation, protein interactions, au...

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Bibliographic Details
Main Authors: Dayne A Beccano-Kelly, Naila eKuhlmann, Igor eTatarnikov, Mattia eVolta, Lise N Munsie, Patrick eChou, Li-Ping eCao, Heather eHan, Lucia eTapia, Matthew J Farrer, Austen J Milnerwood
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-09-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Electrophysiology
Parkinson Disease
Transgenic mice
LRRK2
cortical culture
LRRK2 mutation
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00301/full

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