Phytosterol accumulation results in ventricular arrhythmia, impaired cardiac function and death in mice

Abstract Heart failure (HF) and cardiac arrhythmias share overlapping pathological mechanisms that act cooperatively to accelerate disease pathogenesis. Cardiac fibrosis is associated with both pathological conditions. Our previous work identified a link between phytosterol accumulation and cardiac...

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Bibliographic Details
Main Authors: Hongfei Ge, Gongxin Liu, Tracy M. Yamawaki, Caroline Tao, Shawn T. Alexander, Kimberly Ly, Preston Fordstrom, Artem A. Shkumatov, Chi-Ming Li, Sridharan Rajamani, Mingyue Zhou, Brandon Ason
Format: Article
Language:English
Published: Nature Publishing Group 2021-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-96936-x