PD-1 blockade delays tumor growth by inhibiting an intrinsic SHP2/Ras/MAPK signalling in thyroid cancer cells

PD-1 blockade delays tumor growth by inhibiting an intrinsic SHP2/Ras/MAPK signalling in thyroid cancer cells

Abstract Background The programmed cell death-1 (PD-1) receptor and its ligands PD-L1 and PD-L2 are immune checkpoints that suppress anti-cancer immunity. Typically, cancer cells express the PD-Ls that bind PD-1 on immune cells, inhibiting their activity. Recently, PD-1 expression has also been foun...

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Bibliographic Details
Main Authors: Federica Liotti, Narender Kumar, Nella Prevete, Maria Marotta, Daniela Sorriento, Caterina Ieranò, Andrea Ronchi, Federica Zito Marino, Sonia Moretti, Renato Colella, Efiso Puxeddu, Simona Paladino, Yoshihito Kano, Michael Ohh, Stefania Scala, Rosa Marina Melillo
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Thyroid Cancer
Programmed cell death-1
SHP2 phosphatase
Ras
MAPK signalling
Online Access:https://doi.org/10.1186/s13046-020-01818-1

Internet

https://doi.org/10.1186/s13046-020-01818-1

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