Peptidomimetic-based antibody surrogate for HER2

Peptidomimetic-based antibody surrogate for HER2

Inhibition of human epidermal growth factor receptor 2 mediated cell signaling pathway is an important therapeutic strategy for HER2-positive cancers. Although monoclonal antibodies are currently used as marketed drugs, their large molecular weight, high cost of production and susceptibility to prot...

Full description

Bibliographic Details
Main Authors:	Mengmeng Zheng, Chunpu Li, Mi Zhou, Ru Jia, Fengyu She, Lulu Wei, Feng Cheng, Qi Li, Jianfeng Cai, Yan Wang
Format:	Article
Language:	English
Published:	Elsevier 2021-09-01
Series:	Acta Pharmaceutica Sinica B
Subjects:	HER2 Anti-cancer Peptidomimetics γ-AApeptides Antibody-surrogate
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211383521001556

Similar Items

Development of Bioactive Peptidomimetics
by: She, Fengyu
Published: (2018)

Promising Antibiofilm Activity of Peptidomimetics
by: Rafael Gomes Von Borowski, et al.
Published: (2018-09-01)

Interrogation of Protein Function with Peptidomimetics
by: Bolarinwa, Olapeju
Published: (2018)

Structure Based Antibody-Like Peptidomimetics
by: Mark I. Greene, et al.
Published: (2012-02-01)

Structure-based Design, Synthesis and Applications of a New Class of Peptidomimetics: <em>'Y</em>-AA Peptides and Their Derivatives
by: Su, Ma
Published: (2018)

Cell Permeability Studies of AApeptides and Novel Molecular Probes for AD
by: Bai, Ge
Published: (2016)

Dimeric γ-AApeptides With Potent and Selective Antibacterial Activity
by: Minghui Wang, et al.
Published: (2020-06-01)

Heterocyclic small molecule peptidomimetics
by: Liu, Jing
Published: (2010)

Triazole based peptidomimetics for mimicking protein-protein hot spots
by: Angell, Yu Li
Published: (2010)

Design, Synthesis, Applications of Polymers and Dendrimers
by: Nimmagadda, Alekhya
Published: (2017)

Short Cationic Peptidomimetic Antimicrobials
by: Rajesh Kuppusamy, et al.
Published: (2019-04-01)

Gamma-AApeptides as a New Class of Peptidomimetics: Synthesis, Structures, and Functions
by: Wu, Haifan
Published: (2015)

Gamma AApeptides as Host Defense Peptide Mimics
by: Li, Yaqiong
Published: (2016)

Contributions to peptidomimetic design: predictive computational studies and syntheses of linker molecules
by: Lam, Sang Q.
Published: (2007)

Peptides and Peptidomimetics for Antimicrobial Drug Design
by: Biljana Mojsoska, et al.
Published: (2015-07-01)

Heterocycles in Peptidomimetics and Pseudopeptides: Design and Synthesis
by: Ambra Guarnaccio, et al.
Published: (2012-03-01)

Peptidomimetics Therapeutics for Retinal Disease
by: Dylan E. Parsons, et al.
Published: (2021-02-01)

Advances in Development of Antimicrobial Peptidomimetics as Potential Drugs
by: Natalia Molchanova, et al.
Published: (2017-08-01)

Antibiofilm Peptides and Peptidomimetics with Focus on Surface Immobilization
by: Athina Andrea, et al.
Published: (2018-05-01)

Asymmetric synthesis of propargylamines as amino acid surrogates in peptidomimetics
by: Matthias Wünsch, et al.
Published: (2017-11-01)

Heterocycles as a Peptidomimetic Scaffold: Solid-Phase Synthesis Strategies
by: Aizhan Abdildinova, et al.
Published: (2021-05-01)

Design and Synthesis of Angiotensin IV Peptidomimetics Targeting the Insulin-Regulated Aminopeptidase (IRAP)
by: Andersson, Hanna
Published: (2010)

The Best Peptidomimetic Strategies to Undercover Antibacterial Peptides
by: Joanna Izabela Lachowicz, et al.
Published: (2020-10-01)

A Novel Small Molecular Antibody, HER2-Nanobody, Inhibits Tumor Proliferation in HER2-Positive Breast Cancer Cells In Vitro and In Vivo
by: Yan Yan, et al.
Published: (2021-05-01)

Peptides and Peptidomimetics as Inhibitors of Enzymes Involved in Fibrillar Collagen Degradation
by: Patrycja Ledwoń, et al.
Published: (2021-06-01)

A targeted immunotherapy approach for HER2/neu transformed tumors by coupling an engineered effector domain with interferon-γ
by: Hongtao Zhang, et al.
Published: (2018-04-01)

Similarity analysis, synthesis, and bioassay of antibacterial cyclic peptidomimetics
by: Workalemahu M. Berhanu, et al.
Published: (2012-07-01)

The development of reconstituted translation system for peptidomimetic mRNA display synthesis
by: Stojanovic, Vesna
Published: (2008)

The development of reconstituted translation system for peptidomimetic mRNA display synthesis
by: Stojanovic, Vesna
Published: (2008)

The development of reconstituted translation system for peptidomimetic mRNA display synthesis
by: Stojanovic, Vesna
Published: (2008)

Arg9 facilitates the translocation and downstream signal inhibition of an anti-HER2 single chain antibody
by: Hu Yi, et al.
Published: (2012-07-01)

Polyclonal Antibody against Different Extracellular Subdomains of HER2 Induces Tumor Growth Inhibition in vitro
by: Reza Hosseini-Ghatar, et al.
Published: (2017-09-01)

Implementing antibody-drug conjugates (ADCs) in HER2-positive breast cancer: state of the art and future directions
by: Emanuela Ferraro, et al.
Published: (2021-08-01)

Conjugates of Cryptophycin and RGD or isoDGR Peptidomimetics for Targeted Drug Delivery
by: Adina Borbély, et al.
Published: (2019-06-01)

1,4-Disubstituted 1,2,3-Triazoles as Amide Bond Surrogates for the Stabilisation of Linear Peptides with Biological Activity
by: Lisa-Maria Rečnik, et al.
Published: (2020-08-01)

Isolation and characterization of camelid single-domain antibodies against HER2
by: Greg Hussack, et al.
Published: (2018-12-01)

Identification of Genes Required for Resistance to Peptidomimetic Antibiotics by Transposon Sequencing
by: Alessandra Vitale, et al.
Published: (2020-07-01)

Peptides and Peptidomimetics as Potential Antiobesity Agents: Overview of Current Status
by: Maushmi S. Kumar
Published: (2019-02-01)

Molecular Mechanism of HER2 Rapid Internalization and Redirected Trafficking Induced by Anti-HER2 Biparatopic Antibody
by: Jackie Cheng, et al.
Published: (2020-09-01)

Photoswitchable Peptidomimetics : Synthesis and Photomodulation of Functional Peptides
by: Varedian, Miranda
Published: (2008)