The α-chemokine CXCL14 is up-regulated in the sciatic nerve of a mouse model of Charcot–Marie–Tooth disease type 1A and alters myelin gene expression in cultured Schwann cells

The α-chemokine CXCL14 is up-regulated in the sciatic nerve of a mouse model of Charcot–Marie–Tooth disease type 1A and alters myelin gene expression in cultured Schwann cells

At present the pathogenesis of CMT1A neuropathy, caused by the overexpression of PMP22, has not yet been entirely understood. The PMP22-overexpressing C61 mutant mouse is a suitable animal model, which mimics the human CMT1A disorder. We observed that myelin gene expression in the sciatic nerve of t...

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Bibliographic Details
Main Authors: Elena M. Barbaria, Bianca Kohl, Bettina A. Buhren, Kerstin Hasenpusch-Theil, Fabian Kruse, Patrick Küry, Rudolf Martini, Hans Werner Müller
Format: Article
Language:English
Published: Elsevier 2009-03-01
Series:Neurobiology of Disease
Subjects:
CMT1A
Pmp22
C61 mouse mutant
Myelin
Schwann cells
Cyclin D1
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996108003021

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http://www.sciencedirect.com/science/article/pii/S0969996108003021

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