Effect of Mefloquine, a Gap Junction Blocker, on Circadian Period2 Gene Oscillation in the Mouse Suprachiasmatic Nucleus

Effect of Mefloquine, a Gap Junction Blocker, on Circadian Period2 Gene Oscillation in the Mouse Suprachiasmatic Nucleus

BackgroundIn mammals, the master circadian pacemaker is localized in an area of the ventral hypothalamus known as the suprachiasmatic nucleus (SCN). Previous studies have shown that pacemaker neurons in the SCN are highly coupled to one another, and this coupling is crucial for intrinsic self-sustai...

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Bibliographic Details
Main Authors: Jinmi Koo, Han Kyoung Choe, Hee-Dae Kim, Sung Kook Chun, Gi Hoon Son, Kyungjin Kim
Format: Article
Language:English
Published: Academya Publishing Co. 2015-09-01
Series:Endocrinology and Metabolism
Subjects:
Circadian rhythm
Suprachiasmatic nucleus
Gap junctions
Per2
Real-time bioluminescence
Mefloquine
Online Access:http://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-30-361.pdf

Internet

http://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-30-361.pdf

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