Synaptic network activity induces neuronal differentiation of adult hippocampal precursor cells through BDNF signaling

Synaptic network activity induces neuronal differentiation of adult hippocampal precursor cells through BDNF signaling

Adult hippocampal neurogenesis is regulated by activity. But how do neural precursor cells in the hippocampus respond to surrounding network activity and translate increased neural activity into a developmental program? Here we show that long-term potential (LTP)-like synaptic activity within a cell...

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Bibliographic Details
Main Authors: Harish Babu, Gerardo Ramirez, Klaus Fabel, Josef Bischofberger, Gerd Kempermann
Format: Article
Language:English
Published: Frontiers Media S.A. 2009-09-01
Series:Frontiers in Neuroscience
Subjects:
Hippocampus
Long-Term Potentiation
adult neurogenesis
network oscillation
neurotrophins
precursor cell
Online Access:http://journal.frontiersin.org/Journal/10.3389/neuro.22.001.2009/full

Internet

http://journal.frontiersin.org/Journal/10.3389/neuro.22.001.2009/full

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