Fibrosis: a structural modulator of Sinoatrial Node physiology and dysfunction

Fibrosis: a structural modulator of Sinoatrial Node physiology and dysfunction

Heart rhythm is initialized and controlled by the Sinoatrial Node (SAN), the primary pacemaker of the heart. The SAN is a heterogeneous multi-compartment structure characterized by clusters of specialized cardiomyocytes, enmeshed within strands of connective tissue or fibrosis. Intranodal fibrosis i...

Full description

Bibliographic Details
Main Authors:	Thomas A Csepe, Anuradha eKalyanasundaram, Brian J Hansen, Jichao eZhao, Vadim V Fedorov
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2015-02-01
Series:	Frontiers in Physiology
Subjects:	Aging Atrial Fibrillation Fibrosis Heart Failure Sinoatrial Node sinus node dysfunction
Online Access:	http://journal.frontiersin.org/Journal/10.3389/fphys.2015.00037/full

Similar Items

Genetic Complexity of Sinoatrial Node Dysfunction
by: Michael J. Wallace, et al.
Published: (2021-04-01)

Heart Failure Differentially Modulates Natural (Sinoatrial Node) and Ectopic (Pulmonary Veins) Pacemakers: Mechanism and Therapeutic Implication for Atrial Fibrillation
by: Chao-Shun Chan, et al.
Published: (2019-06-01)

CaMKII in sinoatrial node physiology and dysfunction
by: Yuejin eWu, et al.
Published: (2014-03-01)

Anatomical and clinical aspects of the blood supply of the sinoatrial node Aspectos clínicos e anatômicos da irrigação sanguínea do nó sinoatrial
by: A.C. Lopes, et al.
Published: (1998-03-01)

Junctional Pacemaker May Replace the Sinoatrial Node
by: Min Lin, MD, et al.
Published: (2021-09-01)

Role of sinoatrial node architecture in maintaining a balanced source-sink relationship and synchronous cardiac pacemaking
by: Sathya D Unudurthi, et al.
Published: (2014-11-01)

SARS-CoV-2 Infection Induces Ferroptosis of Sinoatrial Node Pacemaker Cells
by: Chen, S., et al.
Published: (2022)

Atrial and Sinoatrial Node Development in the Zebrafish Heart
by: Kendall E. Martin, et al.
Published: (2021-02-01)

Assembly of the Cardiac Pacemaking Complex: Electrogenic Principles of Sinoatrial Node Morphogenesis
by: Marietta Easterling, et al.
Published: (2021-04-01)

Curcumin can prevent the loss of sinoatrial node cells in methionine-treated rats: A stereological study
by: Atefeh Rahimi, et al.
Published: (2021-06-01)

Synchronization of Pacemaking in the Sinoatrial Node: A Mathematical Modeling Study
by: Daniel Gratz, et al.
Published: (2018-06-01)

Cellular and Molecular Mechanisms of Functional Hierarchy of Pacemaker Clusters in the Sinoatrial Node: New Insights into Sick Sinus Syndrome
by: Di Lang, et al.
Published: (2021-04-01)

Modelling the chronotropic effect of isoprenaline on rabbit sinoatrial node
by: Henggui eZhang, et al.
Published: (2012-07-01)

Recurrent atrial myxoma, right atriotomy, and sinus node dysfunction: A case of interdisciplinary care
by: Erwin Argueta, et al.
Published: (2018-07-01)

Vascularização arterial da região do nó sinoatrial em corações suínos: origem, distribuição e quantificação Arterial vascularization of the sinoatrial node in swine hearts: origin, distribution and quantification
by: Ana P. Vidotti, et al.
Published: (2008-02-01)

Controlling parasympathetic regulation of heart rate: a gatekeeperrole for RGS proteins in the sinoatrial node
by: Alexandra eMighiu, et al.
Published: (2012-06-01)

SINUS NODE DYSFUNCTIONS AND FEATURES OF NORMAL RHYTHM RESTORATION AFTER HEART TRANSPLANTATION
by: S.Y. Shemakin
Published: (2009-05-01)

Importância da anatomia da circulação coronária atrial na operação de Cox para controle da fibrilação atrial The importance of atrial coronary circulation on Cox surgery for control atrial fibrillation
by: Marcelo B. JATENE, et al.
Published: (1999-01-01)

Transcriptome profile of the sinoatrial ring reveals conserved and novel genetic programs of the zebrafish pacemaker
by: Rashid Minhas, et al.
Published: (2021-10-01)

Developmental and Genetic Origins of the Sinoatrial Node
by: Viswanathan, Shiv Kumar
Published: (2008)

Regulation of sinoatrial node and pacemaking mechanisms in health and disease
by: El Khoury, Nabil
Published: (2017)

Origem das artérias dos nós sinoatrial e atrioventricular em população do sul da Índia: um estudo angiográfico Origen de las arterias de los nódulos sinusal y atrioventricular en población del Sur de la India: un estudio angiográfico Origin of the sinoatrial and atrioventricular nodal arteries in South Indians: an angiographic study
by: Lakshmi Ramanathan, et al.
Published: (2009-05-01)

Role of Ca^<2+> Release from Sarcoplasmic Reticulum in Pacemaker Activity of the Sinoatrial Node
by: HONJO, Haruo, et al.
Published: (2002)

Hedgehog signalling controls sinoatrial node development and atrioventricular cushion formation
by: Chaohui Zhang, et al.
Published: (2021-06-01)

Atrial Tachyarrhythmias and Atrial Flutter: the Basics of Diagnostics and Modern Opportunities of Therapy
by: Yu. A. Bunin, et al.
Published: (2019-03-01)

Prediction of sinus node dysfunction in patients with paroxysmal atrial fibrillation and sinus pause
by: Binquan You, et al.
Published: (2016-01-01)

Study of the Effect of Proton Pump Inhibitors on the Development of Hypomagnesemia in Patients with Paroxysmal Atrial Fibrillation on the Background of Autonomic Sinus Node Dysfunction
by: Ya. G. Bozhko, et al.
Published: (2020-01-01)

PDGFRα-Signaling Is Dispensable for the Development of the Sinoatrial Node After Its Fate Commitment
by: Xi Zheng, et al.
Published: (2021-06-01)

Vascularização arterial da região do nó sinoatrial em corações humanos normais
by: Ana Paula Vidotti
Published: (2006)

Vascularização arterial da região do nó sinoatrial em corações humanos normais
by: Vidotti, Ana Paula
Published: (2006)

Severe congenital RYR1-associated myopathy complicated with atrial tachycardia and sinus node dysfunction: a case report
by: Itaru Hayakawa, et al.
Published: (2019-12-01)

A new and simple technique for vagal ganglia ablation in a patient with functional atrioventricular block: Electroanatomical approach
by: Tolga Aksu, et al.
Published: (2018-09-01)

Applying sinus node function testing to evaluate perioperative management for patients suffering from tachycardia‐bradycardia syndrome before atrial fibrillation ablation
by: Dan Han, et al.
Published: (2019-12-01)

Effects of acetylcholine and noradrenalin on action potentials of isolated rabbit sinoatrial and atrial myocytes
by: Arie O. Verkerk, et al.
Published: (2012-05-01)

Clinical Significance of the Head-Up Tilt Test in Improving Prognosis in Patients with Possible Neurally Mediated Syncope
by: Kengo Ayabe, et al.
Published: (2021-09-01)

The Effect of Astragaloside on Pacemaker Current and the Cytoskeleton in Rabbit Sinoatrial Node Cells Under the Ischemia and Reperfusion Condition
by: Ruxiu Liu, et al.
Published: (2018-05-01)

Spontaneous electrical activity of guinea-pig sinoatrial cells under modulation of two different pacemaker mechanisms
by: Francesca Cacciani, et al.
Published: (2014-01-01)

Early atrial fibrillation during acute posterior myocardial infarction: an interplay of ischemia of sinus node artery and atrial arrhythmogenesis.
by: Athanassios Antonopoulos, et al.
Published: (2020-03-01)

Abnormal Ca2+ homeostasis, atrial arrhythmogenesis and sinus node dysfunction in murine hearts modelling RyR2 modification
by: Yanmin eZhang, et al.
Published: (2013-06-01)

Transcriptional and Epigenetic Landscape of Cardiac Pacemaker Cells: Insights Into Cellular Specialization in the Sinoatrial Node
by: Ravi Mandla, et al.
Published: (2021-07-01)