Fibrosis: a structural modulator of Sinoatrial Node physiology and dysfunction

Heart rhythm is initialized and controlled by the Sinoatrial Node (SAN), the primary pacemaker of the heart. The SAN is a heterogeneous multi-compartment structure characterized by clusters of specialized cardiomyocytes, enmeshed within strands of connective tissue or fibrosis. Intranodal fibrosis i...

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Bibliographic Details
Main Authors: Thomas A Csepe, Anuradha eKalyanasundaram, Brian J Hansen, Jichao eZhao, Vadim V Fedorov
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-02-01
Series:Frontiers in Physiology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2015.00037/full