An improved solvent-free synthesis of flunixin and 2-(arylamino) nicotinic acid derivatives using boric acid as catalyst

An improved solvent-free synthesis of flunixin and 2-(arylamino) nicotinic acid derivatives using boric acid as catalyst

Abstract A simple solvent-free protocol for the preparation of flunixin, a potent non-narcotic, non-steroidal anti-inflammatory drugs is reported using boric acid as catalyst. Its salt, flunixin meglumine are then prepared under reflux in EtOH. This sustainable method are then extended for the synth...

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Bibliographic Details
Main Authors: Mahsa Yarhosseini, Shahrzad Javanshir, Zahra Dolatkhah, Mohammad G. Dekamin
Format: Article
Language:English
Published: BMC 2017-12-01
Series:Chemistry Central Journal
Subjects:
Homogeneous catalysis
Solvent-free
Non-steroidal anti-inflammatory drugs (NSAID)
N-Methyl-d-glucamine
Boric acid
Anilino-nicotinic acid
Online Access:http://link.springer.com/article/10.1186/s13065-017-0355-4

Internet

http://link.springer.com/article/10.1186/s13065-017-0355-4

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