Extreme depletion of PIP3 accompanies the increased life span and stress tolerance of PI3K-null C. elegans mutants

Extreme depletion of PIP3 accompanies the increased life span and stress tolerance of PI3K-null C. elegans mutants

The regulation of animal longevity shows remarkable plasticity, in that a variety of genetic lesions are able to extend lifespan by as much as tenfold. Such studies have implicated several key signaling pathways that must normally limit longevity, since their disruption prolongs life. Little is kn...

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Bibliographic Details
Main Authors: Puneet eBharill, Srinivas eAyyadevara, Ramani eAlla, Robert Joseph Shmookler Reis
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-03-01
Series:Frontiers in Genetics
Subjects:
Insulin
Insulin-Like Growth Factor I
Oxidative Stress
Phosphatidylinositol 3-Kinases
Phosphatidylinositols
C. elegans
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2013.00034/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fgene.2013.00034/full

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