Differential effects of buffer pH on Ca2+-induced ROS emission with inhibited mitochondrial complex I and III

Differential effects of buffer pH on Ca2+-induced ROS emission with inhibited mitochondrial complex I and III

Excessive mitochondrial reactive oxygen species (ROS) emission is a critical component in the etiolo-gy of ischemic injury. Complex I and complex III of the electron transport chain are considered the primary sources of ROS emission during cardiac ischemia and reperfusion (IR) injury. Several factor...

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Bibliographic Details
Main Authors: Daniel P Lindsay, Amadou K S Camara, David F Stowe, Ryan eLubbe, Mohammed eAldakkak
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-03-01
Series:Frontiers in Physiology
Subjects:
pH
Complex I
Ca2+
Mitochondrial Permeability Transition Pore
reactive oxygen species (ROS)
complex III
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2015.00058/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2015.00058/full

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