Amplification and Over-Expression of the MDM2 Gene in Human Soft Tissue Tumours

Purpose. Amplification of genetic sequences on chromosome 12q13 is frequently found in soft tissue tumours. However, for the MDM2 gene, over-expression of the MDM2 protein has not always been shown to accompany gene amplification, raising the possibility that amplification of genetic sequences targe...

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Bibliographic Details
Main Authors: Helen Patterson, Diana Barnes, Sandra Gill, James Spicer, Cyril Fisher, Merion Thomas, Robert Grimer, Chris Fletcher, Barry Gusterson, Colin Cooper
Format: Article
Language:English
Published: Hindawi Limited 1997-01-01
Series:Sarcoma
Online Access:http://dx.doi.org/10.1080/13577149778434