2-Oxoester Phospholipase A<sub>2</sub> Inhibitors with Enhanced Metabolic Stability

2-Oxoester Phospholipase A<sub>2</sub> Inhibitors with Enhanced Metabolic Stability

2-Oxoesters constitute an important class of potent and selective inhibitors of human cytosolic phospholipase A<sub>2</sub> (GIVA cPLA<sub>2</sub>) combining an aromatic scaffold or a long aliphatic chain with a short aliphatic chain containing a free carboxylic acid. Althoug...

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Bibliographic Details
Main Authors: Giorgos S. Koutoulogenis, Maroula G. Kokotou, Daiki Hayashi, Varnavas D. Mouchlis, Edward A. Dennis, George Kokotos
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Biomolecules
Subjects:
inhibitor
metabolic stability
α-methylation
oxoesters
phospholipase a<sub>2</sub>
Online Access:https://www.mdpi.com/2218-273X/10/3/491

Internet

https://www.mdpi.com/2218-273X/10/3/491

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