A human polymorphism affects NEDD4L subcellular targeting by leading to two isoforms that contain or lack a C2 domain

<p>Abstract</p> <p>Background</p> <p>Ubiquitination serves multiple cellular functions, including proteasomal degradation and the control of stability, function, and intracellular localization of a wide variety of proteins. NEDD4L is a member of the HECT class of E3 ubi...

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Bibliographic Details
Main Authors: Lalouel Jean-Marc, Weiss Robert B, Blazer-Yost Bonnie L, Garrone Nicholas F, Rohrwasser Andreas
Format: Article
Language:English
Published: BMC 2009-04-01
Series:BMC Cell Biology
Online Access:http://www.biomedcentral.com/1471-2121/10/26