Right place, right time: localisation and assembly of the NLRP3 inflammasome [version 1; peer review: 3 approved]
The NLRP3 inflammasome is a multimeric protein complex that cleaves caspase-1 and the pro-inflammatory cytokines interleukin 1 beta (IL-1β) and IL-18. Dysregulated NLRP3 inflammasome signalling is linked to several chronic inflammatory and autoimmune conditions; thus, understanding the activation me...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
F1000 Research Ltd
2019-05-01
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| Series: | F1000Research |
| Online Access: | https://f1000research.com/articles/8-676/v1 |