Characterization of the Protective Effect of Tetrahydrobiopterin Against S-Nitroso-N -Acetyl-D ,L-Penicillamine Induced Endothelial Cell Injury

Characterization of the Protective Effect of Tetrahydrobiopterin Against S-Nitroso-N -Acetyl-D ,L-Penicillamine Induced Endothelial Cell Injury

The purpose of this study was to characterize the protective effect of tetrahydrobiopterin (BH4), one of the cofactors of nitric oxide (NO) synthase, against NO-induced endothelial cell injury. The addition of S-nitroso-N-acetyl-D,L-penicillamine (SNAP), a NO donor, to endothelial cells induced the...

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Bibliographic Details
Main Authors: Ishii Masakazu, Shimizu Shunichi, Momose Kazutaka, Kiuchi Yuji, Yamamoto Toshinori
Format: Article
Language:English
Published: De Gruyter 1999-02-01
Series:Pteridines
Subjects:
tetrahydrobiopterin
s-nitroso-n-acetyl-d,l-penicillamine
nitric oxide
cell injury
hydrogen peroxide
endothelial cells
Online Access:https://doi.org/10.1515/pteridines.1999.10.1.14

Internet

https://doi.org/10.1515/pteridines.1999.10.1.14

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