Evolutionary dynamics of cancer in response to targeted combination therapy

Evolutionary dynamics of cancer in response to targeted combination therapy

In solid tumors, targeted treatments can lead to dramatic regressions, but responses are often short-lived because resistant cancer cells arise. The major strategy proposed for overcoming resistance is combination therapy. We present a mathematical model describing the evolutionary dynamics of lesio...

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Bibliographic Details
Main Authors: Ivana Bozic, Johannes G Reiter, Benjamin Allen, Tibor Antal, Krishnendu Chatterjee, Preya Shah, Yo Sup Moon, Amin Yaqubie, Nicole Kelly, Dung T Le, Evan J Lipson, Paul B Chapman, Luis A Diaz Jr, Bert Vogelstein, Martin A Nowak
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2013-06-01
Series:eLife
Subjects:
mathematical biology
cancer
stochastic process
targeted therapy
genetic
Online Access:https://elifesciences.org/articles/00747

Internet

https://elifesciences.org/articles/00747

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