Elevated PDK1 Expression Drives PI3K/AKT/MTOR Signaling Promotes Radiation-Resistant and Dedifferentiated Phenotype of Hepatocellular Carcinoma

Elevated PDK1 Expression Drives PI3K/AKT/MTOR Signaling Promotes Radiation-Resistant and Dedifferentiated Phenotype of Hepatocellular Carcinoma

Resistance to radiotherapy (IR), with consequent disease recurrence, continues to limit the efficacy of contemporary anticancer treatment for patients with hepatocellular carcinoma (HCC), especially in late stage. Despite accruing evidence implicating the PI3K/AKT signaling pathway in cancer-promoti...

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Bibliographic Details
Main Authors: Oluwaseun Adebayo Bamodu, Hang-Lung Chang, Jiann-Ruey Ong, Wei-Hwa Lee, Chi-Tai Yeh, Jo-Ting Tsai
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Cells
Subjects:
hepatocellular cancer
hcc
lihc
pdk1
pi3k/akt/mtor pathway
bx795
selective inhibitor
radiotherapy
radioresistance
combination therapy
stemness
dna damage
Online Access:https://www.mdpi.com/2073-4409/9/3/746

Internet

https://www.mdpi.com/2073-4409/9/3/746

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