Evaluation of persistence of resistant variants with ultra-deep pyrosequencing in chronic hepatitis C patients treated with telaprevir.

Evaluation of persistence of resistant variants with ultra-deep pyrosequencing in chronic hepatitis C patients treated with telaprevir.

BACKGROUND & AIMS: Telaprevir, a hepatitis C virus NS3/4A protease inhibitor has significantly improved sustained viral response rates when given in combination with pegylated interferon alfa-2a and ribavirin, compared with current standard of care in hepatitis C virus genotype 1 infected patien...

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Main Authors: Xiomara V Thomas, Joep de Bruijne, James C Sullivan, Tara L Kieffer, Cynthia K Y Ho, Sjoerd P Rebers, Michel de Vries, Hendrik W Reesink, Christine J Weegink, Richard Molenkamp, Janke Schinkel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3407168?pdf=render

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http://europepmc.org/articles/PMC3407168?pdf=render

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