Transcriptional Induction of Cystathionine γ-Lyase, a Reactive Sulfur-Producing Enzyme, by Copper Diethyldithiocarbamate in Cultured Vascular Endothelial Cells

Transcriptional Induction of Cystathionine γ-Lyase, a Reactive Sulfur-Producing Enzyme, by Copper Diethyldithiocarbamate in Cultured Vascular Endothelial Cells

As toxic substances can enter the circulating blood and cross endothelial monolayers to reach parenchymal cells in organs, vascular endothelial cells are an important target compartment for such substances. Reactive sulfur species protect cells against oxidative stress and toxic substances, includin...

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Bibliographic Details
Main Authors: Tomoya Fujie, Akane Takahashi, Musubu Takahashi, Takato Hara, Asuka Soyama, Kosho Makino, Hideyo Takahashi, Chika Yamamoto, Yoshito Kumagai, Hiroshi Naka, Toshiyuki Kaji
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:International Journal of Molecular Sciences
Subjects:
endothelial cell
copper diethyldithiocarbamate
cystathionine γ-lyase
mitogen-activated protein kinase
hypoxia-inducible factor-1
bio-organometallics
Online Access:https://www.mdpi.com/1422-0067/21/17/6053

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https://www.mdpi.com/1422-0067/21/17/6053

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