Overexpression of wild-type human APP in mice causes cognitive deficits and pathological features unrelated to Aβ levels

Overexpression of wild-type human APP in mice causes cognitive deficits and pathological features unrelated to Aβ levels

Transgenic mice expressing mutant human amyloid precursor protein (APP) develop an age-dependent amyloid pathology and memory deficits, but no overt neuronal loss. Here, in mice overexpressing wild-type human APP (hAPPwt) we found an early memory impairment, particularly in the water maze and to a l...

Full description

Bibliographic Details
Main Authors: Ana-María Simón, Lucio Schiapparelli, Pablo Salazar-Colocho, Mar Cuadrado-Tejedor, Luis Escribano, Rakel López de Maturana, Joaquín Del Río, Alberto Pérez-Mediavilla, Diana Frechilla
Format: Article
Language:English
Published: Elsevier 2009-03-01
Series:Neurobiology of Disease
Subjects:
Alzheimer's disease
APP
Amyloid
Tau
Synapse
Hippocampus
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996108002787

Internet

http://www.sciencedirect.com/science/article/pii/S0969996108002787

Similar Items