ADAMTS-5 Decreases in Aortas and Plasma From Aortic Dissection Patients and Alleviates Angiotensin II-Induced Smooth Muscle-Cell Apoptosis

ADAMTS-5 Decreases in Aortas and Plasma From Aortic Dissection Patients and Alleviates Angiotensin II-Induced Smooth Muscle-Cell Apoptosis

Background: Acute aortic dissection (AAD) is associated with degeneration of the aortic media and accompanied by vascular extracellular matrix (ECM) remodeling. Recently, a disintegrin and metalloproteinase with thrombospondin type 1 motifs-5 (ADAMTS-5) has been reported to be involved in ECM remode...

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Bibliographic Details
Main Authors: Tao Zeng, Jianting Gan, Yu Liu, Lei Shi, Zhengde Lu, Yan Xue, Rixin Xiong, Ling Liu, Zicong Yang, Yingzhong Lin, Jun Yuan
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
acute aortic dissection
ADAMTS-5
extracellular matrix
smooth muscle cells
matrix metalloproteinase
apoptosis
Online Access:https://www.frontiersin.org/article/10.3389/fcvm.2020.00136/full

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https://www.frontiersin.org/article/10.3389/fcvm.2020.00136/full

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