Low Expression of miR-466f-3p Sustains Epithelial to Mesenchymal Transition in Sonic Hedgehog Medulloblastoma Stem Cells Through Vegfa-Nrp2 Signaling Pathway

Low Expression of miR-466f-3p Sustains Epithelial to Mesenchymal Transition in Sonic Hedgehog Medulloblastoma Stem Cells Through Vegfa-Nrp2 Signaling Pathway

High-throughput analysis has improved the knowledge of medulloblastoma (MB), the leading cause of cancer related death in children, allowing a better comprehension of the key molecular pathways in MB pathogenesis. However, despite these advances, 30% of patients still die from the disease and surviv...

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Bibliographic Details
Main Authors: Zein Mersini Besharat, Claudia Sabato, Agnese Po, Francesca Gianno, Luana Abballe, Maddalena Napolitano, Evelina Miele, Felice Giangaspero, Alessandra Vacca, Giuseppina Catanzaro, Elisabetta Ferretti
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Pharmacology
Subjects:
medulloblastoma
sonic hedgehog medulloblastoma cancer stem cells
epithelial to mesenchymal transition
vegfa
Nrp2
miR-466f-3p
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01281/full

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https://www.frontiersin.org/article/10.3389/fphar.2018.01281/full

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