Synaptopathy Mechanisms in ALS Caused by C9orf72 Repeat Expansion

Synaptopathy Mechanisms in ALS Caused by C9orf72 Repeat Expansion

Amyotrophic Lateral Sclerosis (ALS) is a complex neurodegenerative disease caused by degeneration of motor neurons (MNs). ALS pathogenic features include accumulation of misfolded proteins, glutamate excitotoxicity, mitochondrial dysfunction at distal axon terminals, and neuronal cytoskeleton change...

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Bibliographic Details
Main Authors: Agnes L. Nishimura, Natalia Arias
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Cellular Neuroscience
Subjects:
synaptic transmission
dendrites
dendritic spines
synaptopathies
neurodegeneration
amyotrophic lateral sclerosis
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2021.660693/full

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https://www.frontiersin.org/articles/10.3389/fncel.2021.660693/full

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