Plasticity between Epithelial and Mesenchymal States Unlinks EMT from Metastasis-Enhancing Stem Cell Capacity

Plasticity between Epithelial and Mesenchymal States Unlinks EMT from Metastasis-Enhancing Stem Cell Capacity

Forced overexpression and/or downregulation of proteins regulating epithelial-to-mesenchymal transition (EMT) has been reported to alter metastasis by changing migration and stem cell capacity of tumor cells. However, these manipulations artificially keep cells in fixed states, while in vivo cells m...

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Bibliographic Details
Main Authors: Evelyne Beerling, Daniëlle Seinstra, Elzo de Wit, Lennart Kester, Daphne van der Velden, Carrie Maynard, Ronny Schäfer, Paul van Diest, Emile Voest, Alexander van Oudenaarden, Nienke Vrisekoop, Jacco van Rheenen
Format: Article
Language:English
Published: Elsevier 2016-03-01
Series:Cell Reports
Subjects:
cancer
epithelial-to-mesenchymal transition (EMT)
intravital microscopy
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716301371

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http://www.sciencedirect.com/science/article/pii/S2211124716301371

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