FKBPL and its peptide derivatives inhibit endocrine therapy resistant cancer stem cells and breast cancer metastasis by downregulating DLL4 and Notch4

FKBPL and its peptide derivatives inhibit endocrine therapy resistant cancer stem cells and breast cancer metastasis by downregulating DLL4 and Notch4

Abstract Background Optimising breast cancer treatment remains a challenge. Resistance to therapy is a major problem in both ER- and ER+ breast cancer. Tumour recurrence after chemotherapy and/or targeted therapy leads to more aggressive tumours with enhanced metastatic ability. Self-renewing cancer...

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Bibliographic Details
Main Authors: Lana McClements, Stephanie Annett, Anita Yakkundi, Martin O’Rourke, Andrea Valentine, Nermeen Moustafa, Abdelrahim Alqudah, Bruno M. Simões, Fiona Furlong, Amy Short, Stuart A. McIntosh, Helen O. McCarthy, Robert B. Clarke, Tracy Robson
Format: Article
Language:English
Published: BMC 2019-04-01
Series:BMC Cancer
Subjects:
Metastasis
Triple negative breast cancer
Estrogen receptor
Endocrine therapy
Breast cancer stem cells
FKBPL
Online Access:http://link.springer.com/article/10.1186/s12885-019-5500-0

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http://link.springer.com/article/10.1186/s12885-019-5500-0

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