Metabolic engineering with ATP-citrate lyase and nitrogen source supplementation improves itaconic acid production in Aspergillus niger

Metabolic engineering with ATP-citrate lyase and nitrogen source supplementation improves itaconic acid production in Aspergillus niger

Abstract Background Bio-based production of organic acids promises to be an attractive alternative for the chemicals industry to substitute petrochemicals as building-block chemicals. In recent years, itaconic acid (IA, methylenesuccinic acid) has been established as a sustainable building-block che...

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Bibliographic Details
Main Authors: Abeer H. Hossain, Roy van Gerven, Karin M. Overkamp, Peter S. Lübeck, Hatice Taşpınar, Mustafa Türker, Peter J. Punt
Format: Article
Language:English
Published: BMC 2019-09-01
Series:Biotechnology for Biofuels
Subjects:
Itaconic acid
Aspergillus niger
Transcriptome analysis
Metabolic engineering
ATP-citrate lyase
Fermentation optimization
Online Access:http://link.springer.com/article/10.1186/s13068-019-1577-6

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http://link.springer.com/article/10.1186/s13068-019-1577-6

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