Polymeric Micelles for the Enhanced Deposition of Hydrophobic Drugs into Ocular Tissues, without Plasma Exposure

Polymeric Micelles for the Enhanced Deposition of Hydrophobic Drugs into Ocular Tissues, without Plasma Exposure

Commercial topical ocular formulations for hydrophobic actives rely on the use of suspensions or oil in water emulsions and neither of these formulation modalities adequately promote drug penetration into ocular tissues. Using the ocular relevant hydrophobic drug, cyclosporine A (CsA), a non-irritan...

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Bibliographic Details
Main Authors: Ijeoma F. Uchegbu, Jan Breznikar, Alessandra Zaffalon, Uche Odunze, Andreas G. Schätzlein
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Pharmaceutics
Subjects:
cyclosporine A
Molecular Envelope Technology (MET)
N-palmitoyl-N-monomethyl-N,N-dimethyl-N,N,N-trimethyl-6-O-glycolchitosan (GCPQ)
eye
penetration enhancer
Online Access:https://www.mdpi.com/1999-4923/13/5/744

Internet

https://www.mdpi.com/1999-4923/13/5/744

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