Myeloid cell-specific Irf5 deficiency stabilizes atherosclerotic plaques in Apoe–/– mice

Myeloid cell-specific Irf5 deficiency stabilizes atherosclerotic plaques in Apoe–/– mice

Objective: Interferon regulatory factor (IRF) 5 is a transcription factor known for promoting M1 type macrophage polarization in vitro. Given the central role of inflammatory macrophages in promoting atherosclerotic plaque progression, we hypothesize that myeloid cell-specific deletion of IRF5 is pr...

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Bibliographic Details
Main Authors: Julia Leipner, Tsai-Sang Dederichs, Alexander von Ehr, Simon Rauterberg, Carolin Ehlert, Julian Merz, Bianca Dufner, Natalie Hoppe, Katja Krebs, Timo Heidt, Constantin von zur Muehlen, Peter Stachon, Klaus Ley, Dennis Wolf, Andreas Zirlik, Christoph Bode, Ingo Hilgendorf, Carmen Härdtner
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:Molecular Metabolism
Subjects:
Atherosclerosis
Interferon regulatory factor 5
Macrophage polarization (M1, M2)
Plaque stabilization
Anti-inflammation
Aortic macrophages
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877821000958

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http://www.sciencedirect.com/science/article/pii/S2212877821000958

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