Anatomy of protein disorder, flexibility and disease-related mutations.

Anatomy of protein disorder, flexibility and disease-related mutations.

Integration of protein structural information with human genetic variation and pathogenic mutations is essential to understand molecular mechanisms associated with the effects of polymorphisms on protein interactions and cellular processes. We investigate occurrences of non-synonymous SNPs in ordere...

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Bibliographic Details
Main Authors: Hui-Chun eLu, Sun Sook eChung, Arianna eFornili, Franca eFraternali
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-08-01
Series:Frontiers in Molecular Biosciences
Subjects:
Protein Disorder
protein flexibility
Non-synonymous SNPs
Order-Disorder Propensity
Disease-related Mutations
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmolb.2015.00047/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmolb.2015.00047/full

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