Sae2 and Rif2 regulate MRX endonuclease activity at DNA double-strand breaks in opposite manners

Sae2 and Rif2 regulate MRX endonuclease activity at DNA double-strand breaks in opposite manners

Summary: The Mre11-Rad50-Xrs2 (MRX) complex detects and processes DNA double-strand breaks (DSBs). Its DNA binding and processing activities are regulated by transitions between an ATP-bound state and a post-hydrolysis cutting state that is nucleolytically active. Mre11 endonuclease activity is stim...

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Bibliographic Details
Main Authors: Antonio Marsella, Elisa Gobbini, Corinne Cassani, Renata Tisi, Elda Cannavo, Giordano Reginato, Petr Cejka, Maria Pia Longhese
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Cell Reports
Subjects:
checkpoint
double-strand breaks
MRX
Mre11-Rad50
Rad53
Rif2
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721002205

Internet

http://www.sciencedirect.com/science/article/pii/S2211124721002205

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