Identification and characterization of the Cucurbitacins, a novel class of small-molecule inhibitors of Tropomyosin receptor kinase a

Identification and characterization of the Cucurbitacins, a novel class of small-molecule inhibitors of Tropomyosin receptor kinase a

Abstract Background NGF-TrkA is well known to play a key role in propagating and sustaining pruritogenic signals, which form the pathology of chronic pruritus. Inhibition of NGF-TrkA is a known strategy for the treatment of pruritus. In the present paper, we describe the identification, in vitro cha...

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Bibliographic Details
Main Authors: Yueling Zhong, Hong Xu, Yi Zhong, Xuemiao Zhang, Ting Zeng, Limei Li, Gaojie Xu, Minhui Li, Jin Liu, Tai Yang
Format: Article
Language:English
Published: BMC 2019-11-01
Series:BMC Complementary and Alternative Medicine
Subjects:
Cucurbitacins
TrkA
Kinase
Inhibitors
Pruritus
Online Access:http://link.springer.com/article/10.1186/s12906-019-2709-z

Internet

http://link.springer.com/article/10.1186/s12906-019-2709-z

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