Pan-pathway based interaction profiling of FDA-approved nucleoside and nucleobase analogs with enzymes of the human nucleotide metabolism.

Pan-pathway based interaction profiling of FDA-approved nucleoside and nucleobase analogs with enzymes of the human nucleotide metabolism.

To identify interactions a nucleoside analog library (NAL) consisting of 45 FDA-approved nucleoside analogs was screened against 23 enzymes of the human nucleotide metabolism using a thermal shift assay. The method was validated with deoxycytidine kinase; eight interactions known from the literature...

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Bibliographic Details
Main Authors: Louise Egeblad, Martin Welin, Susanne Flodin, Susanne Gräslund, Liya Wang, Jan Balzarini, Staffan Eriksson, Pär Nordlund
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3360617?pdf=render

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http://europepmc.org/articles/PMC3360617?pdf=render

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