Increase in PD-L1 expression after pre-operative radiotherapy for soft tissue sarcoma

Increase in PD-L1 expression after pre-operative radiotherapy for soft tissue sarcoma

Soft tissue sarcomas (STS) have minimal expression of PD-L1, a biomarker for PD-1 therapy efficacy. Radiotherapy (RT) has been shown to increase PD-L1 expression pre-clinically. We examined the expression of PD-L1, pre- and post-RT, in 46 Stage II-III STS patients treated with pre-operative RT (50–5...

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Bibliographic Details
Main Authors: Kirtesh R. Patel, Anthony Martinez, John M. Stahl, Suzanna J. Logan, Adam J. Perricone, Matthew J. Ferris, Zachary S. Buchwald, Mudit Chowdhary, Keith A. Delman, David K. Monson, Shervin V. Oskouei, Nicholas B. Reimer, Kenneth Cardona, Mark A. Edgar, Karen D. Godette
Format: Article
Language:English
Published: Taylor & Francis Group 2018-07-01
Series:OncoImmunology
Subjects:
soft tissue sarcoma
pd-l1
immunotherapy
radiation
Online Access:http://dx.doi.org/10.1080/2162402X.2018.1442168

Internet

http://dx.doi.org/10.1080/2162402X.2018.1442168

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