High Levels of miR-7-5p Potentiate Crizotinib-Induced Cytokilling and Autophagic Flux by Targeting RAF1 in NPM-ALK Positive Lymphoma Cells

High Levels of miR-7-5p Potentiate Crizotinib-Induced Cytokilling and Autophagic Flux by Targeting RAF1 in NPM-ALK Positive Lymphoma Cells

Anaplastic lymphoma kinase positive anaplastic large cell lymphomas (ALK+ ALCL) are an aggressive pediatric disease. The therapeutic options comprise chemotherapy, which is efficient in approximately 70% of patients, and targeted therapies, such as crizotinib (an ALK tyrosine kinase inhibitor (TKI))...

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Bibliographic Details
Main Authors: Domenico Sorrentino, Julie Frentzel, Géraldine Mitou, Rafael B. Blasco, Avédis Torossian, Coralie Hoareau-Aveilla, Chiara Pighi, Manon Farcé, Fabienne Meggetto, Stéphane Manenti, Estelle Espinos, Roberto Chiarle, Sylvie Giuriato
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Cancers
Subjects:
anaplastic large cell lymphoma
NPM-ALK
autophagy
cell death
crizotinib
combined therapy
Online Access:https://www.mdpi.com/2072-6694/12/10/2951

Internet

https://www.mdpi.com/2072-6694/12/10/2951

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