The BMP2 variant L51P restores the osteogenic differentiation of human mesenchymal stromal cells in the presence of intervertebral disc cells

The BMP2 variant L51P restores the osteogenic differentiation of human mesenchymal stromal cells in the presence of intervertebral disc cells

Spinal fusion is hampered by the presence of remaining intervertebral disc (IVD) tissue and leads to spinal non-union. While the exact mechanism remains unknown, we hypothesise that factors preventing disc ossification, such as antagonists of the bone morphogenetic proteins (BMP), could be responsib...

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Bibliographic Details
Main Authors: A Tekari, RD May, DA Frauchiger, SCW Chan, LM Benneker, B Gantenbein
Format: Article
Language:English
Published: AO Research Institute Davos 2017-02-01
Series:European Cells & Materials
Subjects:
Spinal fusion
intervertebral disc
stem cells
coculture
osteogenesis
bone morphogenetic proteins
antagonists of bone morphogenetic proteins
BMP2 variant L51P
Online Access:http://www.ecmjournal.org/papers/vol033/pdf/v033a15.pdf

Internet

http://www.ecmjournal.org/papers/vol033/pdf/v033a15.pdf

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