Mild Iron Overload as Seen in Individuals Homozygous for the Alpha-1 Antitrypsin Pi*Z Variant Does Not Promote Liver Fibrogenesis in <i>HFE</i> Knockout Mice

Mild Iron Overload as Seen in Individuals Homozygous for the Alpha-1 Antitrypsin Pi*Z Variant Does Not Promote Liver Fibrogenesis in <i>HFE</i> Knockout Mice

The presence of the homozygous &#8216;Pi*Z&#8217; variant of alpha-1 antitrypsin (AAT) (&#8216;Pi*ZZ&#8217; genotype) predisposes to liver fibrosis development, but the role of iron metabolism in this process remains unknown. Therefore, we assessed iron metabolism and variants in the...

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Bibliographic Details
Main Authors: Nurdan Guldiken, Karim Hamesch, Shari Malan Schuller, Mahmoud Aly, Cecilia Lindhauer, Carolin V. Schneider, Malin Fromme, Christian Trautwein, Pavel Strnad
Format: Article
Language:English
Published: MDPI AG 2019-11-01
Series:Cells
Subjects:
iron metabolism
α1-antitrypsin deficiency
rare liver disease
genetic liver disease
<i>serpina1</i>
<i>hfe</i>
liver fibrosis
Online Access:https://www.mdpi.com/2073-4409/8/11/1415

Internet

https://www.mdpi.com/2073-4409/8/11/1415

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