CD4 T cells mediate both positive and negative regulation of the immune response to HIV infection: complex role of T follicular helper cells and Regulatory T cells in pathogenesis

CD4 T cells mediate both positive and negative regulation of the immune response to HIV infection: complex role of T follicular helper cells and Regulatory T cells in pathogenesis

HIV-1 infection results in chronic activation of cells in lymphoid tissue, including T cells, B cells and myeloid lineage cells. The resulting characteristic hyperplasia is an amalgam of proliferating host immune cells in the adaptive response, increased concentrations of innate response mediators d...

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Bibliographic Details
Main Authors: Chansavath ePhetsouphanh, Yin eXu, John eZaunders
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-01-01
Series:Frontiers in Immunology
Subjects:
HIV Infections
Lymphoid Tissue
regulatory T cells
CD4
T follicular helper cells
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00681/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00681/full

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