Polymalic Acid Tritryptophan Copolymer Interacts with Lipid Membrane Resulting in Membrane Solubilization

Anionic polymers with membrane permeation functionalities are highly desirable for secure cytoplasmic drug delivery. We have developed tritryptophan containing copolymer (P/WWW) of polymalic acid (PMLA) that permeates membranes by a mechanism different from previously described PMLA copolymers of tr...

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Bibliographic Details
Main Authors: Hui Ding, Irving Fox, Rameshwar Patil, Anna Galstyan, Keith L. Black, Julia Y. Ljubimova, Eggehard Holler
Format: Article
Language:English
Published: Hindawi Limited 2017-01-01
Series:Journal of Nanomaterials
Online Access:http://dx.doi.org/10.1155/2017/4238697