Modulating the RNA processing and decay by the exosome: altering Rrp44/Dis3 activity and end-product.

Modulating the RNA processing and decay by the exosome: altering Rrp44/Dis3 activity and end-product.

In eukaryotes, the exosome plays a central role in RNA maturation, turnover, and quality control. In Saccharomyces cerevisiae, the core exosome is composed of nine catalytically inactive subunits constituting a ring structure and the active nuclease Rrp44, also known as Dis3. Rrp44 is a member of th...

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Main Authors: Filipa P Reis, Ana Barbas, A A Klauer-King, Borislava Tsanova, Daneen Schaeffer, Eduardo López-Viñas, Paulino Gómez-Puertas, Ambro van Hoof, Cecília M Arraiano
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3827031?pdf=render

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http://europepmc.org/articles/PMC3827031?pdf=render

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